Table 2.
Worst grade of on-treatment CTC toxicity
| Acute toxicity | Group | Worst CTC grade |
P∗ | OR for G3/4† | 99% CI | P‡ | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | 0 | 1 | 2 | 3 | 4 | ||||||
| Any toxicity | sRT | 120 | 4 (3.3) | 31 (25.8) | 55 (45.8) | 26 (21.7) | 4 (3.3) | .73 | 0.79 | 0.33, 1.87 | .48 |
| RHDVRT | 95 | 4 (4.2) | 23 (24.2) | 49 (51.6) | 17 (17.9) | 2 (2.1) | |||||
| Genitourinary | sRT | 117 | 23 (19.7) | 41 (35.0) | 33 (28.2) | 17 (14.5) | 3 (2.6) | .57 | 1.00 | 0.39, 2.60 | .99 |
| RHDVRT | 94 | 18 (19.1) | 30 (31.9) | 31 (33.0) | 14 (14.9) | 1 (1.1) | |||||
| Gastrointestinal | sRT | 117 | 25 (21.4) | 59 (50.4) | 27 (23.1) | 6 (5.1) | 0 | .85 | 0.38 | 0.04, 3.26 | .23 |
| RHDVRT | 94 | 25 (26.6) | 37 (39.4) | 30 (31.9) | 2 (2.1) | 0 | |||||
Abbreviations: CI = confidence interval; CTC = Common Toxicity Criteria; G = grade; OR = odds ratio. Other abbreviations as in Table 1.
Includes worst grade of toxicity reported across all weeks of treatment (ie, weeks 1-4 if patient received 55 Gy/20 fx/4 wk or weeks 1-7 if patient received 64 Gy/32 fx/6.5 wk. Values in parentheses are percentages.
P value from Van Elteren (stratified Mann-Whitney) test comparing the distribution of grades between treatment groups.
Odds ratio for G3 or G4 toxicity in RHDVRT group compared with sRT group, adjusted for chemotherapy randomization.
P value from Mantel-Haenszel test comparing the proportion of G3/4 toxicities between groups, stratified by chemotherapy randomization.