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. 2013 Sep;142(3):241–255. doi: 10.1085/jgp.201311018

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© 2013 De Lange et al.

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Figure 1. — Diagrammatic representation of the domain structure of cMyBP-C. Ig domains are shown as hexagons, fibronectin-domains are shown as circles, and regions with a less organized domain structure are shown as light blue filled rectangles. Cardiac-specific regions are shown in red. Ig and fibronectin domains are numbered as C0–C10 from the N terminus to the C terminus. The positions of the three physiologically relevant phosphorylation sites (Ser275, Ser284, and Ser304) in the MyBPC motif (M-motif) are indicated by the yellow ovals. The position of the E258K mutation in the C1 domain, adjacent to the MyBPC motif is shown above the diagram. The binding sites for light meromyosin (LMM), myosin-S2 (S2), and titin, as well as the region essential for correct A-band incorporation and the region of N-terminal cMyBP-C implicated in interactions with components of the thin filament, are indicated by the double-headed arrows below the diagram.