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. 2013 Sep;142(3):181–190. doi: 10.1085/jgp.201311012

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© 2013 Gamal El-Din et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — Comparison of recovery from inactivation for NavAb WT and NavAb/N49K. (A) Recovery from inactivation for NavAb WT studied with a 100-ms pre-depolarization (red protocol and circles) and for NavAb/N49K studied with a 4-s pre-depolarization (black protocol and triangles). Pre-depolarizations to induce inactivation were followed after a variable recovery interval by a test depolarization to −10 mV. Peak current measured during the test depolarization was normalized to the peak current during the pre-depolarization and plotted as a function of the recovery interval. (B) Recovery from inactivation for NavAb/N49K studied as described above but using a 10-s pre-depolarization to induce inactivation. (C) Eight superimposed depolarizations to 0 mV for NavAb/N49K applied at 0.2 Hz from an HP of −120 mV (left-hand traces) were followed by a 2-min maintained depolarization to 0 mV. The membrane potential was then returned to −120 mV, and the 0.2-Hz train of depolarizations to 0 mV was resumed (right-hand traces). The first depolarization, applied 10 ms after returning to −120 mV, resulted in the trace with no inward current. Current traces elicited by nine additional subsequent depolarizations are shown superimposed.