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. 2013 Sep;142(3):275–288. doi: 10.1085/jgp.201310975

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© 2013 Perry et al.

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Figure 2. — Scanning mutagenesis of the Kv11.1 channel S4 helix. (A–C) Shifts, relative to WT, in log(K_eq,0) values for alanine (A), serine (B), and tryptophan (C) mutagenesis scans of S4 residues spanning from Gly522 to Lys538. Data are presented as means ± SEM for n = 3–20 cells (see Table S1). Dashed lines indicate Δlog(K_eq,0) > ±0.5 log units, which has been shown previously to be the minimum perturbation required to derive an accurate Φ-value (Cymes et al., 2002; Wang et al., 2011). Mutations that fulfill this minimum requirement are indicated by closed bars, whereas mutations with Δlog(K_eq,0) < 0.5 log units are indicated by open bars. *, mutant channels that failed to express or expressed poorly.