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. 2013 Sep;142(3):275–288. doi: 10.1085/jgp.201310975

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© 2013 Perry et al.

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Figure 3. — Families of mutations at important Kv11.1 channel S4 residues. (A and B) Shifts in log(K_eq,0), relative to WT, for families of mutations at charged (A) or hydrophobic (B) residues that were identified as important determinants for inactivation gating from our mutagenesis scans of the S4 helix. Mutations are indicated by single–amino acid code on the y axis. Data are presented as means ± SEM for n = 4–14 cells (see Table S1). Mutations that cause a significant perturbation to inactivation, measured as Δlog(K_eq,0) > ±0.5 log units relative to WT, are indicated by closed bars, whereas mutations with Δlog(K_eq,0) < ±0.5 log units are indicated by open bars. *, mutant channels that failed to express or expressed poorly.