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. 2013 Sep;142(3):275–288. doi: 10.1085/jgp.201310975

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© 2013 Perry et al.

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Figure 7. — Only combinations of S4 mutants alter the voltage sensitivity of Kv11.1 channel inactivation. (A and B) Dot plots showing the linear slope values calculated from the derived unidirectional rate constants (shown as black lines in Fig. 1 D) for the onset of (k_inact; A) and recovery from (k_rec; B) inactivation for groups of mutants (to Ala, Ser, and Trp) at each residue in the S4 domain, as well as the double and triple mutants. Slope values indicate the voltage dependence of the forward (inactivation; A) and reverse (recovery from inactivation; B) gating transitions. The mean of all mutations at each individual residue falls within ±2 standard deviations (gray box) of the mean calculated from all single S4 mutants.