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. 2013 Sep;142(3):275–288. doi: 10.1085/jgp.201310975

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© 2013 Perry et al.

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Figure 9. — Homology model of the Kv11.1 channel. View parallel to the membrane of an amplified region of a Kv11.1 channel homology model created using the Kv1.2/2.1 chimera crystal structure (Long et al., 2007) as a template, according to the alignment shown in Fig. S3. The amplified region is indicated by the boxed region of the entire four-subunit homology model shown in the inset. Hydrophobic residues on the S4 helix (Leu529, Leu532, and Val535) of one subunit (sub1; shown in green, with residues colored orange) face toward hydrophobic residues on the S5 helix (Ile560, Leu564, and Ile567) of the neighboring subunit (sub2; shown in blue, with residues colored purple). The arrow represents a cavity filled by lipid in the Kv1.2/2.1 crystal structure.