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. 2013 Sep;142(3):191–206. doi: 10.1085/jgp.201310984

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© 2013 Lewis and Raman

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Figure 3. — β4 peptide–mediated acceleration of current decay and reduction of steady-state current in CW channels. (A) Voltage protocol (top) and representative transient Na currents in WT (black) and ATX-modified WT (green), in the absence and presence of 200 µM β4 peptide. Currents normalized to peak current amplitude for comparison. (B) As in A, with CW (blue) and ATX-modified CW (red) channels. (C) Mean decay rate of WT Na currents as a function of voltage ±β4 peptide and ±ATX. Currents measured as time for currents to decay by 25% of the peak current amplitude. (D) As in C, for CW Na channels. (E) Mean current remaining after 100 ms of depolarization, measured over last 1 ms of voltage step, relative to the peak transient current at that voltage. (F) As in E, for CW channels. Within-cell comparisons ±ATX for each cell; WT, n = 6; CW, n = 5; WT plus β4, n = 5; CW plus β4, n = 6.