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. 2013 Sep;142(3):191–206. doi: 10.1085/jgp.201310984

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© 2013 Lewis and Raman

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — Tail currents and β4 peptide–induced resurgent Na currents in WT channels. (A) Voltage protocol and representative transient and tail and/or resurgent currents in WT channels without and with β4 peptide. Black, control; red, ATX. (B) Tail and resurgent currents in control solutions, as in A, expanded. (C) Tail and resurgent currents in ATX, as in A, expanded. (D) Mean peak resurgent current amplitude versus voltage in WT (black) and ATX-modified WT (green) channels. Currents normalized to peak transient current at 0 mV in each cell. Dashed lines, corrected for incomplete activation of transient current at 0 mV. (E) Mean time to peak resurgent current versus voltage. (F) Mean decay time constant (τ) of resurgent current, fit with a single exponential. Within-cell comparisons ±ATX; −β4, n = 6; +β4, n = 5.