Table 3.
Parameters of recovery from inactivation and/or block
| Condition | −ATX | +ATX | P-value (−ATX vs. +ATX) | ||||||
| τfast | % τfast | τslow | τfast | % τfast | τslow | τfast | % τfast | τslow | |
| ms | ms | ms | ms | ||||||
| 0 mV | |||||||||
| WT (n = 8) | 2.7 ± 0.1 | 89 ± 2 | 149 ± 21 | 1.6 ± 0.1 | 80 ± 2 | 111 ± 25 | <0.001 | <0.01 | 0.4 | 
| WT + β4 (n = 7) | 2.8 ± 0.1 | 86 ± 2 | 118 ± 19 | 1.6 ± 0.1 | 81 ± 3 | 171 ± 36 | <0.001 | 0.1 | 0.3 | 
| P (−β4 vs. +β4) | 0.6 | 0.4 | 0.3 | 0.9 | 0.7 | 0.2 | |||
| CW (n = 7) | 5.1 ± 0.5 | 47 ± 3 | 189 ± 15 | n/a | n/a | 278 ± 38 | n/a | n/a | 0.1 | 
| CW + β4 (n = 7) | 3.1 ± 0.1 | 65 ± 4 | 205 ± 21 | 1.4 ± 0.1 | 77 ± 3 | 272 ± 54 | <0.001 | <0.001 | 0.3 | 
| P (−β4 vs. +β4) | <0.005 | <0.005 | 0.6 | n/a | n/a | 0.9 | |||
| +60 mV | |||||||||
| WT (n = 4) | 2.4 ± 0.1 | 89 ± 3 | 94 ± 16 | 1.5 ± 0.1 | 79 ± 3 | 174 ± 21 | <0.05 | <0.01 | <0.01 | 
| WT + β4 (n = 5) | 2.5 ± 0.1 | 88 ± 1 | 133 ± 36 | 1.4 ± 0.1 | 85 ± 3 | 185 ± 34 | <0.005 | 0.4 | <0.05 | 
| P (−β4 vs. +β4) | 0.5 | 0.7 | 0.4 | 0.7 | 0.1 | 0.8 | |||
| CW (n = 6) | 6.4 ± 1.7 | 25 ± 6 | 205 ± 18 | n/a | n/a | 261 ± 58 | n/a | n/a | 0.4 | 
| CW + β4 (n = 7) | 0.8 ± 0.1 | 66 ± 4 | 184 ± 20 | 0.6 ± 0.1 | 81 ± 3 | 148 ± 53 | <0.005 | <0.05 | 0.5 | 
| P (−β4 vs. +β4) | <0.005 | <0.001 | 0.5 | n/a | n/a | 0.2 | |||