Figure 2.

The organization and structure of chromatin within the nucleus is coupled with the regulation of gene expression (125). (a) Genes tethered to the nuclear lamina are silenced, whereas genes that are present in the centre of the nucleus are not. In addition, enhancers anchored to the lamina are restricted from interacting with their target promoters. (b) The movement of genes away from the lamina results in their upregulation, as they move to a more permissive transcriptional domain, and the movement of enhancers allows them to communicate properly and regulate the expression profile of their target gene.