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. 2013 Jun 10;41(15):7420–7428. doi: 10.1093/nar/gkt536

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Distribution of fitness effects of non-synonymous codon substitutions in (A and B) HB36.4 and (C and D) HB80.3. The distribution is partitioned into codon changes with 1-, 2- and 3-base changes. The red dashed vertical line indicates the enrichment value of the parental genes, and the blue dashed horizontal bar indicates the fraction of all possible mutations of the gene that are point mutations. Enrichment values for parental genes are slightly greater than zero because most mutations have a negative effect on fitness. (E) Median enrichment values for types of codon substitutions. Distributions based on codon enrichment values instead of amino acid enrichment values are provided in Supplementary Figure S1.