Fig. 1.

GRK5 mediates inflammatory response in the CLP model of polymicrobial sepsis: GRK5 WT and KO mice were subjected to CLP surgery and peritoneal (a) and plasma (b) fluids were collected 12 h after surgery as described in Materials and Methods. IL-6, IL-10, TNFα, IL12/23 (total p40) and MCP-1 were measured in these two fluid samples using ELISA kits from eBiosciences (n = 12 for WT and n = 9 for KO for the 12-hour time point).* p < 0.05, ** p < 0.01, *** p < 0.001 compared to the corresponding septic WT groups.