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CD74-ROS expressing cells are highly invasive and metastatic. (A, B) Representative photomicrographs of H&E stained paraffin embedded cross sections of subcutaneous xenograft tumors from clonal FIG-ROS and CD74-ROS expressing Rat1 cells. Arrows point to invasive areas. Stars mark the locations of ribs. T; tumor, LN; lymph node. Scale bars: (A) 500 μm (B) 250 μm. C, graphical representation of CD74-ROS invasiveness as measured by in vitro Boyden chamber matrigel invasion assays.
