Fig. 1.

a Representative T2-weighted images of a HIV+ subject indicate the voxel positions in the frontal cortex, white matter (top left), and basal ganglia (top right) examined in both HIV+ and control subjects. b Representative single voxel proton MR spectra from the frontal cortex region of a HIV+ subject at study entry (left spectrum) and 6 months later (right spectrum) during early HIV infection. Six months spectrum was normalized to baseline creatine levels (3.044 ppm). Significant elevations in choline can be seen in this subject after 6 months