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Histone modifications orchestrate binding of key DDR factors to DSB chromatin. (A) Histone modifications and their associated enzymes at DSB chromatin. (B) Histone modifications and their binding partners or regulators. See text for details. Note that the figure illustrates the ubiquitination-dependent recruitment of 53BP1 to DSBs, but it is not thought to directly bind to ubiquitinylated proteins.
