Table 1.
Histone posttranslational modifications associated with the DDR
| Histone-modifying enzymes | Name (organism) | Proposed molecular function—targets |
|---|---|---|
| K-kinases | ATM/ATR (Sc-h) | H2A.X S139 (h), S129 (Sc) |
| WSTF (h) | H2A.X Y142 | |
| Cdc7 (Sc) | H3 T45 | |
| Aurora B | H3 S10, S28 | |
| Bub1 | H2A S121 | |
| Haspin | H3 T3 | |
| K-acetyltransferases | Hat1 (Sc) | H4 K5, K12 |
| NuA4/Tip60 (Sc, Dm, h) | H4 K5, K8, K12, K16, | |
| H2A.Z K3, K8, K10, K14 | ||
| Gcn5 (Sc, h) | H3 K9, K14, K18 | |
| CBP/p300 | H3 K18, H4 K5, K8, K12, K16 | |
| RTT109 (Sc) | H3 K56ac | |
| K-deacetylases | Rpd3 (Sc, h) | H3, H4 |
| Hda1 (Sc) | H2A.Z, H2B, H3 | |
| Sir2/SIRT1, 6 (Sc, h, m) | H4 K16, | |
| HDAC1, 2, 4 (h) | H2A, H2B, H3, H4 | |
| K-methyltransferases | SET1 (Sc) | H3 K4 |
| PR-Set7/Set8 (h) | H3 K20me | |
| MMSET1 (h) | H4 K20me2, 3 | |
| EZH2 (h) | H3 K27 | |
| Dot1 (Sc) | H3 K79 | |
| Ubiquitilases | RNF8 (h) | H2A |
| RNF168 (h) | H2A | |
| Rad6/RNF20-40 (Sc, h) | H2B K120ub (h), K123 (Sc) |