Table 1.
ESCRT proteins in MVB sorting and cytokinesis
| The complexes | Function | Necessary for MVB sorting? | Necessary for cytokinesis? | Disease associations | |
|---|---|---|---|---|---|
| Yeast | Human | ||||
| ESCRT-0 | Binds ubiquitinated cargo and PtdIns(3)P | Cancer | |||
| Vps27 | Hrs | Yes | No | ||
| Hse1 | STAM1/2 | No | No | ||
| ESCRT-I | Binds ESCRT-0,-II, and ubiquitinated cargo; localizes to midbody during cell division | Cancer, AIDS | |||
| Vps23 | Tsg101 | Yes | Yes | ||
| Vps28 | Vps28 | Yes | Yes | ||
| Vps37 | Vps37A-D | Yes | Yes | ||
| Mvb12 | hMvb12A, B | Slight defect | n.d. | ||
| — | UBAP1 | Yes | No | ||
| ESCRT-II | Binds ESCRT-I and nucleates ESCRT-III; binds ubiquitinated cargo and PtdIns(3)P | ||||
| Vps36 | EAP45 | Yes | No | ||
| Vps22 | EAP30 | Yes | No | ||
| Vps25 | EAP20 | Yes | No | ||
| ESCRT-III | Sculpts MVB vesicles and drives cytokinesis | FTD3, AIDS HD Parkinson’s | |||
| Vps20 | CHMP6 | Yes | No? | ||
| Snf7 | CHMP4A-D | Yes | Yes | ||
| Vps24 | CHMP3 | Yes | Yes | ||
| Vps2 | CHMP2A, B | Yes | Yes | ||
| Vps60 | CHMP5 | Yes | Yes | ||
| Bro1 | Alix | Yes | Yes | ||
| Ist1 | IST1 | No | Yes | ||
| Did2 | CHMP1 | Yes | Yes | ||
| AAA ATPases | Drives ESCRT-III disassembly severs MT during abscission | AIDS | |||
| Vps4 | Vps4A and B | Yes | Yes | ||
| — | Spastin | Yes | Yes | HSP | |
| Other MIT domain proteins | |||||
| Vta1 | LIP5 | Slight defect | Yes | ||
| — | MITD1 | No | Yes | ||
| Additional notable proteins | Recruits ESCRTs to midbody phosphorylates CHMP4C; cell division checkpoint | ||||
| — | CEP55 | No | Yes | ||
| — | Aurora B | No | Yes | ||
FTD3, frontotemporal dementia linked to chromosome 3; AIDS, acquired immune deficiency syndrome; HD, Huntington’s disease; HSP, herditary spastic paraplegia; n.d., no data.