Table 2.
Crude and multivariable Cox regression analyses of factors associated with mortality in HIV patients with tuberculous meningitis.
| Crude analysis | Complete case MA | Multiple imputation MA | ||||
|---|---|---|---|---|---|---|
| N = 176 | N = 203 | |||||
| HR | 95% CI | aHR | 95% CI | aHR | 95% CI | |
| iATR | ||||||
| New | 1 | 1 | 1 | |||
| Standard | 1.82* | (1.095–3.020) | 1.88* | (1.081–3.261) | 2.05* | (1.209–3.462) |
| Age (years) | ||||||
| <35 | 1.06 | (0.711–1.573) | 1.16 | (0.695–1.922) | 1.09 | (0.692–1.729) |
| >35 | 1 | 1 | 1 | |||
| Gender | ||||||
| Female | 1.05 | (0.683–1.601) | 0.93 | (0.538–1.594) | 0.85 | (0.514–1.405) |
| Male | 1 | 1 | 1 | |||
| Disadvantaged community | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.59* | (1.052–2.399) | 1.19 | (0.717–1.963) | 1.27 | (0.811–1.974) |
| Homeless | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 0.89 | (0.361–2.201) | 1.05 | (0.382–2.874) | 1.02 | (0.378–2.766) |
| Illiterate | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.31 | (0.877–1.954) | 1.12 | (0.662–1.889) | 1.18 | (0.736–1.881) |
| Depressed consciousness | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.36 | (0.913–2.021) | 1.21 | (0.751–1.939) | 1.30 | (0.852–1.987) |
| Previous tuberculosis | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.09 | (0.657–1.792) | 1.54 | (0.795–2.966) | 1.50 | (0.845–2.678) |
| Months on ART | ||||||
| >6 months | 0.63 | (0.367–1.098) | 0.82 | (0.403–1.678) | 0.76 | (0.399–1.439) |
| <6 months | 0.50* | (0.291–0.852) | 0.59 | (0.310–1.142) | 0.56* | (0.311–0.995) |
| No ART | 1 | 1 | 1 | |||
| CD4 count (cells/μL) | ||||||
| ≤50 | 3.04* | (1.885–4.901) | 1.93* | (1.086–3.427) | 1.95* | (1.132–3.372) |
| 51–100 | 1.34 | (0.766–2.346) | 1.24 | (0.665–2.322) | 1.27 | (0.707–2.279) |
| >100 | 1 | 1 | 1 | |||
| Sodium (mEq/L) | ||||||
| ≤135 | 1 | 1 | 1 | |||
| >135 | 0.58* | (0.358–0.956) | 0.66 | (0.379–1.133) | 0.70 | (0.410–1.181) |
| Albumin (g/dL) | ||||||
| ≤2.5 | 3.95* | (2.163–7.231) | 3.66* | (1.490–9.008) | 3.14* | (1.433–6.898) |
| 2.6–3.8 | 1.92* | (1.139–3.227) | 1.95* | (1.029–3.691) | 1.92* | (1.093–3.380) |
| >3.8 | 1 | 1 | 1 | |||
| Haemoglobin (g/dL) | ||||||
| ≤9 | 1.48 | (0.973–2.239) | 0.78 | (0.421–1.428) | 0.76 | (0.434–1.330) |
| >9 | 1 | 1 | 1 | |||
*P value < 0.05; aHR, adjusted hazard ratio; ART: antiretroviral therapy; iATR: initial antituberculous regimen; HR: hazard ratio; MA: multivariable analysis.