Table 2.
Effect of pretreatment of EE and CPZ treated rats with PPARα receptor antagonist (GW6471) 1 mg/kg/d i.p 30 min before fenofibrate, bezafibrate, or gemfibrozil on biochemical parameters and bile flow rate.
| Parameter | GW6471 | EE + CPZ | Feno + GW | Beza + GW | Gem + GW |
|---|---|---|---|---|---|
| ALP U/L | 226.9 ± 22.9a | 556.59 ± 69.5∗b | 514.98 ± 57.4∗b∧ | 493.66 ± 35.4∗ab∧ | 411.82 ± 22,6∗ab∧ |
| GGT U/L | 8.69 ± 1.3a | 19.9 ± 5.4∗b | 16.56 ± 4.85∗b∧ | 9.01 ± 2.25∗ab∧ | 15.97 ± 5.23∗b∧ |
| AST U/mL | 67.93 ± 9.6a | 150.69 ± 15.6∗b | 148.18 ± 20.96∗b∧ | 98.03 ± 11.19∗a∧bF | 111.79 ± 19.04∗ab∧F |
| ALT U/mL | 49.137 ± 7.99a | 85.5 ± 11.83∗b | 86.132 ± 11.97∗b∧ | 77.21 ± 13.36∗ab∧ | 73.33 ± 7.398∗ab∧F |
| TBA μmole/L | 16.116 ± 4.104a | 81.75 ± 20.2∗b | 79.65 ± 15.92∗b∧ | 72.85 ± 19.35∗a∧bF | 61.69 ± 14.9∗ab∧F |
| Direct Bil. μmole/L | 0.9025 ± 0.316a | 2.065 ± 0.36∗b | 1.97 ± 0.418∗b∧ | 1.387 ± 0.28∗a∧bF | 1.286 ± 0.329∗ab∧F |
| T. BIL. μmole/L | 1.97 ± 0.722a | 5.42 ± 1.39∗b | 5.637 ± 1.83∗b∧ | 3.786 ± 1.318∗a∧bF | 3.353 ± 0.79∗ab∧F |
| IL-1β pg/mL | 0.109 ± 0.013a | 0.27 ± 0.059∗b | 0.2435 ± 0.099∗b∧ | 0.1694 ± 0.043∗ab∧ | 0.1541 ± 0.037∗ab∧F |
| TNFα ng/mL | 0.101 ± 0.09a | 0.1648 ± 0.29∗b | 0.155 ± 0.2∗b∧ | 0.0939 ± 0.05∗ab∧F | 0.1232 ± 0.01∗a∧bF |
| MDA μmole/gm tissue | 29.15 ± 11.53a | 75.96 ± 12.84∗b | 69.38 ± 21.3∗b∧ | 59.67 ± 19.11∗ba∧ | 46.12 ± 15.9∗ab∧F |
| Bile flow rate μL/min/Kg b·wt | 19.87 ± 1.09a | 3.8675 ± 2.3∗b | 5.13 ± 1.33∗b∧ | 7.98 ± 1.34∗ab∧F | 10.055 ± 1.02∗ab∧F |
ALP: alkaline phosphatase; GGT: gamma glutamyl transpeptidase; AST: aspartate aminotransferase; ALT: alanine aminotransferase; TBA: total bile acids; Direct Bil: direct bilirubin; T. Bil.: total bilirubin; IL-1β: interleukin-1beta; TNFα: tumor necrosis factor alpha; MDA: malondialdehyde; EE: ethinylestradiol; CPZ: chlorpromazine; Feno: fenofibrate; Beza: bezafibrate; Gem: gemfibrozil; GW: GW6471. Data are presented as mean ± SD. *Significantly different from control, asignificantly different from EE and CPZ groups, bsignificantly different from GW6471 group, ∧significantly different from corresponding group not receiving GW6471, Fsignificantly different from (feno + GW6471) group at P < 0.05.