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. Author manuscript; available in PMC: 2014 May 22.
Published in final edited form as: Neuron. 2013 May 22;78(4):580–582. doi: 10.1016/j.neuron.2013.05.008

Figure 1. A Model for G Protein Signaling in the SCN.

Figure 1

In this simplified model, VIP-expressing clock neurons in the SCN receive inputs via Gq, which increases intracellular Ca2+ levels and modifies clock gene oscillations that, in turn, determine the timing of VIP release. VPAC2, the VIP receptor, activates Gs signaling in SCN neurons that do not express VIP and this alters clock gene oscillations in these downstream clock neurons.