. Author manuscript; available in PMC: 2013 Aug 27.

Published in final edited form as: Respir Med. 2012 Apr 12;106(7):1040–1047. doi: 10.1016/j.rmed.2012.03.006

Table 6.

Histopathologic findings of surgical lung biopsy specimens after stratification on HRCT pattern.

HRCT pattern	Histopathology by surgical lung biopsy
Isolated airways disease (n =3)	Cellular bronchiolitis with lymphoplasmacytic inflammation, organizing pneumonia, increased perivascular collagen Organizing pneumonia with granulomata and fibrosis Cellular bronchiolitis with lymphoplasmacytic inflammation and patchy cellular interstitial inflammation
Isolated ILD (n =4)	UIP with lymphoplasmacytic inflammation, pleuritis, increased perivascular collagen UIP with lymphoplasmacytic inflammation, DIP-like macrophages UIP with lymphoplasmacytic inflammation DIP with lymphoplasmacytic inflammation, pleuritis
Airways disease and ILD (n =6)	Bronchiolitis with UIP with granulomata, lymphoplasmacytic inflammation, germinal centers, increased perivascular collagen, DIP-like macrophages UIP with lymphoplasmacytic inflammation, DIP-like macrophages AIP, with DIP-like macrophages, lymphoplasmacytic inflammation, organizing pneumonia NSIP with lymphoplasmacytic inflammation Bronchiolitis and organizing pneumonia with lymphoplasmacytic and eosinophilic inflammation UIP with lymphoplasmacytic inflammation, DIP-like macrophages
Combined pulmonary fibrosis with emphysema (n =1)	UIP with lymphoplasmacytic inflammation and emphysema

AIP=acute interstitial pneumonia, DIP=desquamative interstitial pneumonia, NSIP=non-specific interstitial pneumonia, UIP=usual interstitial pneumonia, and ILD=interstitial lung disease.