Table 1.
Baseline patient characteristcs in the overall study population and in the groups with or without High On-Treatment Platelet Reactivity (HPR).
| Overall group | HPR | No HPR | P-value | |
|---|---|---|---|---|
| n=335 | n=109 | n=226 | ||
| Age | 65.0 [58.0, 73.0] | 66.0 [58.4, 74.0] | 65.0 [57.8, 72.0] | 0.28 |
| Male | 71.0% (238/335) | 61.5% (67/109) | 75.7% (171/226) | 0.01 |
| Body surface area (m2) | 1.93 [1.79, 2.13] | 1.95 [1.80, 2.16] | 1.93 [1.79, 2.12] | 0.70 |
| Platelet Count | 196 [164, 232] | 189 [158, 220] | 198 [167, 236] | 0.037 |
| Prior MI | 21.5% (72/335) | 18.3% (20/109) | 23.0% (52/226) | 0.40 |
| Stroke/TIA | 6.6% (22/335) | 3.7% (4/109) | 8.0% (18/226) | 0.16 |
| Congestive Heart Failure | 7.5% (25/335) | 8.3% (9/109) | 7.1% (16/226) | 0.67 |
| Hypertension | 77.9% (261/335) | 79.8% (87/109) | 77.0% (174/226) | 0.67 |
| Hyperlipidemia | 80.5% (269/334) | 81.5% (88/108) | 80.1% (181/226) | 0.88 |
| Diabetes Mellitus | 31.6% (106/335) | 45.9% (50/109) | 24.8% (56/226) | 0.0002 |
| Chronic Renal Insufficiency | 9.3% (31/335) | 14.7% (16/109) | 6.6% (15/226) | 0.026 |
| Current Smoking | 9.9% (33/335) | 8.3% (9/109) | 10.6% (24/226) | 0.56 |
| Additional Medication usage | ||||
| β-blocker | 66.9% (220/329) | 67.3% (72/107) | 66.7% (148/222) | 1.00 |
| Statins | 70.9% (234/330) | 66.7% (72/108) | 73.0% (162/222) | 0.25 |
| ACE I | 34.8% (115/330) | 32.4% (35/108) | 36.0% (80/222) | 0.54 |
| Anatomical Location of Target Lesion | ||||
| Left Main | 2.1% (7/333) | 3.7% (4/108) | 1.3% (3/225) | 0.22 |
| Left Anterior Descending (LAD) | 44.4% (148/333) | 47.2% (51/108) | 43.1% (97/225) | 0.48 |
| LAD branch (Diagonal) | 3.6% (12/333) | 3.7% (4/108) | 3.6% (8/225) | 1.00 |
| Left Circumflex (LCx) | 14.1% (47/333) | 9.3% (10/108) | 16.4% (37/225) | 0.093 |
| LCx branch (Ramus, OM, LPL, LPDA) | 8.1% (27/333) | 9.3% (10/108) | 7.6% (17/225) | 0.67 |
| Right Coronary Artery (RCA) | 24.6% (82/333) | 23.1% (25/108) | 25.3% (57/225) | 0.69 |
| RCA branch (AVcon, RPDA, RPL) | 3.0% (10/333) | 3.7% (4/108) | 2.7% (6/225) | 0.73 |
Diabetes = diabetes requiring medical therapy, Chronic renal insufficiency = Glomerular filtration rate < 60 ml/min/1.72m2, CHF = NYHA class III or IV, MI = myocardial infarction, TIA = transient ischemic attack. Coronary anatomy: LAD = left anterior descending, LCx = left circumflex, Ramus = ramus intermedius, OM = obtuse marginal, LPL = left postero-lateral, LPDA = left posterior descending, RCA = right coronary artery, AVcon = A–V continuation, RPDA = right posterior descending, RPL = right posterolateral. Continuous variables are summarized as median [interquartile range] (count/n). Categorical variables are summarized as % (count/n).