Figure 6.

Effect of GYY4137 on superoxide production, LOX-1 expression, cytokines and ICAM-1 in aortas of apoE^−/− mice. Dihydroethidium (DHE) staining of aortic sections for superoxide production (A-a) and quantification of superoxide production(A-b). Western blot analyses and quantification of LOX-1 protein expression (B). Quantification of aortic TNF-α mRNA (C), IL-6 mRNA (D) and ICAM-1mRNA (E) was carried out by real-time PCR. ^‡P < 0.05, compared with WT mice, ^§P < 0.05, compared with apoE^−/− + NS (n = 5).