Figure 5.
Effect of reference compounds haloperidol and clozapine (A), Lu AF21934 (B) and Lu AF32615 (C) on amphetamine–induced hyperactivity in Albino Swiss mice. The compounds were given 30 or 60 min before amphetamine administration. Locomotor activity was monitored over an 80 min session immediately following an injection of amphetamine. Values in parentheses represent the doses of the compounds in mg·kg−1.The data are presented as mean ± SEM. #P < 0.001 versus control group and ***P < 0.001, **P < 0.01 versus amphetamine-treated group; one-way anova and Dunnett's test.