Figure 7.

The suppression of DOI-induced head twitches by Lu AF21934 (A) and reference compound clozapine (B) in wild type (WT) and mGlu₄^−/− (KO) mice. The compounds were given 60 min before DOI (2.5 mg·kg⁻¹) administration, and immediately after DOI the test begun. The values represent the number of head twitches (mean ± SEM) during a 20-min session. Values in parentheses represent the doses of the compounds in mg·kg⁻¹. The data is presented as means ± SEM. ^#P < 0.05 versus DOI-treated WT mice, *P < 0.05 versus DOI-treated WT mice and **P < 0.01 versus DOI-treated WT group; one-way anova and Dunnett's test.