Fig 9.

β₃-Integrin expression in keratinocytes is HIF1α regulated and enhances wound healing. (A) Potential HRE for β₃-integrin. Mouse β₃-integrin is located on chromosome 11, which contains a potential HRE 15.1 kb upstream of the start codon, consisting of an HIFα binding site (HBS) and an HIFα ancillary sequence (HAS) in its promoter. (B) Model of enhanced reepithelialization of skin wounds in K14 cKO mice compared to that in their WT littermates, representing the β₃-integrin (Itgβ3)-induced migration in the tip of the keratinocyte tongue (blue arrow, direction of migration) and reduced TGFβ activity, leading to more proliferation.