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Foxa3-null mice are more insulin sensitive than WT mice. (A to D) GTT (A) and ITT (C) assays in adult WT (n = 5) and Foxa3-null (KO) mice (n = 5) fed a HFD and quantification of area under the curve (AUC) (B and D). (E) Serum parameters in WT (n = 5) and Foxa3-null (KO) mice (n = 5) after HFD regimen. Data represent means ± SEM (**, P < 0.01; *, P < 0.05).
