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. 2013 Aug;33(16):3343–3353. doi: 10.1128/MCB.01213-12

Fig 5.

Fig 5

CTBP2 is also involved in RA-induced differentiation of human promyelocytic leukemia cells. (A) mRNA expression of CTBP2 and RXRα in HL-60 cells expressing pRS control or vectors targeting CTBP2 or RXRα was examined by qRT-PCR. Error bars denote SD. (B and C) CTBP2 is required for transcriptional induction of RA target genes in HL-60 cells in response to RA. Shown are the results from mRNA expression analysis of CYP26A1 (B) and RARβ (C) in HL-60 cells expressing the pRS control or vectors targeting CTBP2 or RXRα cultured in the absence or presence of 1 μM RA for 48 h. Error bars denote SD. (D) CTBP2 is involved in RA-induced differentiation in human promyelocytic leukemia cells. Shown are results from HL-60 cells expressing the pRS control or vectors targeting CTBP2 or RXRα cultured in the absence or presence of 1 μM RA for 48 h. Flow cytometric analysis of CD11b expression was used to assess differentiation.