Msx2 interacts with Sp3 only. FLAG-Msx2 was cotransfected with transcription factors (TF) Pax9, Dlx2, Lhx6, Lhx8, Snail, Sp3, and Lef1 into C2C12 and C3H10T1/2 cells. Only Sp3 and not the other Msx1 interactors tested was coimmunoprecipitated with Msx2 both in C2C12 and C3H10T1/2 cells.