Fig 4.

Genome-wide distributions of HMGN1 in neural progenitor cells. (A) Global distribution of HMGN1 throughout the genome. (B) Enhanced HMGN1-binding strength at promoters. (C) HMGN1 binds to promoters containing CpG islands. Note that 92% of the HMGN1-binding promoters are CpG island promoters and that 70% of the CpG island promoters bind HMGN1, regardless of expression levels. (D) Average HMGN1 signals near the transcription start site (TSS) of different groups of genes. Black line, Top40 genes with CpG island promoters; red line, Top40 genes with non-CpG island promoters; blue line, Bot40 genes with CpG island promoters; green line, Bot40 genes with non-CpG island promoters. RPM, reads per million. The inset indicates average expression values (in log₂) in the four groups of genes. (E) An example of colocalization of HMGN1, CpG island promoters, and H3K4Me3 histone mark. (F) Overlapping of HMGN1-binding promoter and H3K4Me3-positive promoters.