Fig 3.
2-20 F is a mucogenic factor in RSV infection. BALB/cJ mice were mock infected (n = 3) or infected with 105 PFU of A2 (n = 5), 2-20 (n = 5), or A2–2-20F (n = 5), and lungs were harvested on day 8 postinfection. The PAS-positive area was determined for each airway. (A) Results for >200 individual airways are shown per group. Each symbol represents one airway. †, significant difference compared to mock-infected animals (P < 0.001); *, significant difference compared to A2-infected animals (P < 0.05, ANOVA); $, significant difference compared to A2-infected animals (P < 0.001, ANOVA). (B) The same percent PAS positivity data as in panel A plotted against the size of all airways. The results are representative of those from two experiments with similar results.