Fig 2.

Comparison of sensitivity to hTRIM5α for viruses carrying subtype B and subtype A CA sequences. Viral fold sensitivity to hTRIM5α was measured as described in the Fig. 1 legend and is shown for subtype B viruses versus subtype A1 CRF02_AG and CRF01_AE viruses. Symbols are color coded according to the patient groups indicated in the legend and described in the Fig. 1 legend. Statistical analysis was performed using the Mann-Whitney test. This analysis was directed at identifying the effect of mutations selected by CTL targeting HLA-B*57- or HLA-B*27-restricted epitopes on hTRIM5α sensitivity according to virus subtype. Consequently, results for HLA-B*57⁻/B*27⁻ patients whose viruses did not express B57 footprint mutations (red dots), which showed low hTRIM5α sensitivity regardless of virus subtype, were excluded from the statistical analysis.