Fig 5.

Capsid sequence of viruses from HLA-B*27⁺ patients. Shown are the subtype and partial amino acid sequence of CA for viruses from HLA-B*27⁺ patients whose viral load in the absence of treatment was >500 RNA copies/ml (viremic) or <500 copies/ml (controller). The HLA-B*27-restricted KK10 epitope (amino acids 263 to 272) and the position of common compensatory mutations (amino acids 173, 252, and 260) have been highlighted. Note that viruses from patient 57C4, who was both HLA-B*27⁺ and HLA-B*57⁺, had the T242N mutation in the HLA-B*57-restricted TW10 epitope, which is likely to have contributed to their increased hTRIM5α sensitivity.