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N3-H274Y contains novel Y274 and W295 conformations. (A) Y274 in N3-H274Y is flexible and adopts two conformations, one pointing toward E276, and another oriented away from E276. (B) Y274 in N3-H274Y only adopts the conformation away from E276 when binding oseltamivir, and W295 overturns to accommodate the novel Y274 conformation. (C) Y274 and W295 in the N3-H274-zanamivir complex still adopt the typical conformations found in other NAs.
