Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Group specific interactions of the 240-, 270-, and 290-loops. (A and B) VN04N1-oseltamivir (orange) and VN04N1-H274Y-oseltamivir (cyan) contain a strong hydrogen bond network among the 240-, 270-, and 290-loops, and W295 forms a π-π interaction with H296, which is only conserved in N1. (C and D) N3-oseltamivir (yellow) and N3-H274Y-oseltamivir (green) contain a weaker hydrogen bond network among these three loops, and no interaction can be formed between W295 and K296.
