Table 1.

IC₅₀s and 95% CIs for the inhibition of wild-type N3 by classical NA inhibitors and for the inhibition of N1, N2, N3, and their H274Y variants by oseltamivir

Inhibitor	Concn (nM)
	IC50	95% CI
Wild-type N3
Oseltamivir	0.50	0.42–0.61
Zanamivir	0.51	0.44–0.60
Laninamivir	1.31	1.15–1.50
Peramivir	0.42	0.37–0.47
CS-8958	350	282–434
N1, N2, and N3 and their H274Y variants
N3-H274	8.31	7.70–8.97
09N1	0.67	0.61–0.73
09N1- H274Y	779	714–850
57N2	0.61	0.48–0.77
57N2-H274Y	1.68	1.28–2.17