Table 1.
Characteristics of the variable region of heavy chains and light chains of the vaccine-elicited rabbit MAbs
| Epitope | RMAb | Heavy chain |
Light chain |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IGHV |
IGHJ |
CDR3 length (aa) | IGKV |
IGKJ |
CDR3 length (aa) | ||||||
| Germ line | Mutation (%) | Germ line | Mutation (%) | Germ line | Mutation (%) | Germ line | Mutation (%) | ||||
| V3 | R56 | S40*01 | 6 | 4*01 | 9 | 6 | S15*01 | 9 | 2*01 | 10 | 13 |
| R20 | S40*01 | 6 | 4*01 | 5 | 23 | S3*01 | 8 | 2*01 | 3 | 12 | |
| R43 | S40*01 | 6 | 4*01 | 6 | 6 | S37*01 | 8 | 2*01 | 3 | 11 | |
| C4 | R53 | S40*01 | 10 | 4*01 | 9 | 17 | S49*01 | 9 | 2*01 | 13 | 15 |
| C1 | R15 | S40*01 | 27 | 4*01 | 11 | 6 | S33*01 | 12 | 2*01 | 10 | 10 |
| R35 | S40*01 | 26 | 4*01 | 11 | 6 | S52*01 | 10 | 2*01 | 3 | 9 | |
| R41 | S40*01 | 26 | 4*01 | 11 | 6 | S52*01 | 9 | 2*01 | 9 | 10 | |
| C5 | R13 | S45*01 | 5 | 4*01 | 9 | 6 | S15*01 | 11 | 2*01 | 8 | 12 |
| Conformational/unknown | R27 | S40*01 | 23 | 4*01 | 15 | 15 | S10*01 | 11 | 2*01 | 10 | 10 |
| R28 | S40*01 | 10 | 4*01 or 2*01 | 11 | 6 | S52*01 | 9 | 2*01 | 10 | 13 | |
| R31 | S45*01 | 22 | 2*01 | 12 | 14 | S52*01 or S64*01 | 7 | 2*01 | 5 | 11 | |
| R52 | S40*01 | 8 | 4*01 or 4*02 | 3 | 20 | S3*01 | 8 | 2*01 | 3 | 12 | |