Fig 1.

Reovirus strains differ in the capacity to replicate in the respiratory tract and spread systemically. CBA/J mice were inoculated intranasally with 10⁷ PFU of reovirus strain T1L, T3D^C, or T3D^F. Organs were resected at the indicated times postinoculation, and viral titers in the lungs (A), mediastinal lymph nodes (B), and spleen (C) were determined by plaque assay using L929 cells. Results are expressed as mean viral titers for 6 to 9 mice per time point. Error bars indicate standard errors of the means (SEM). One (P < 0.05), two (P < 0.01), and three (P < 0.001) asterisks reflect significance relative to titers recovered from animals inoculated with T3D^F (Mann-Whitney test).