Fig 2.
Reovirus systemic dissemination is not dependent on respiratory viral load. CBA/J mice were inoculated intranasally with 107 PFU T3DC, 107 PFU T3DF, or 3 × 108 PFU T3DF. Organs were resected at the indicated times postinoculation, and viral titers in the lungs (A) and spleen (B) were determined by plaque assay using L929 cells. Results are shown from one representative experiment of two performed with 3 mice per time point. Error bars indicate SEM. An asterisk (P < 0.05 by Mann-Whitney test) reflects significance relative to titers recovered from animals inoculated with T3DF.