Fig 7.

Each of the polymorphic coding sequences in the T3D S1 gene influences respiratory infection and dissemination. CBA/J mice were inoculated intranasally with 10⁷ PFU of T3D^F, rsT3D^F/T3D^CS1-77, or rsT3D^F/T3D^CS1-1234. Organs were harvested at the indicated times postinoculation, and viral titers in the lungs (A), MLN (B), and spleen (C) were determined by plaque assay using L929 cells. Results are expressed as mean viral titers for two independent experiments with 3 to 4 mice per time point. Error bars indicate SEM. There were no statistically significant differences between groups in panels A and B.