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c-Src promotes tyrosine phosphorylation of IRF4. 293 cells in 60-mm dishes were transfected with 1 μg c-Src and 1 μg IRF4 expression plasmids or their mutants. Cells were collected 48 h posttransfection and analyzed for IRF4 phosphorylation with p-IRF4(Y121/124). (A) c-Src kinase activity is required for IRF4 phosphorylation. (B) c-Src targets the sites Y121/124 of IRF4. WB, Western blot.
