Table 1.

Specific amino acid substitutions in the hexon protein of Ad5 in H(43m-43), H(43s-43), and H(48-48) backbones

Hexon protein	H(43m-43)		H(43s-43)		H(48-48)
	Ad5 aaa inserted	Ad43 aa inserted	Ad5 aa deleted	Ad43 aa inserted	Ad5 aa deleted	Ad48 aa inserted
HVR 1	136–165	136–153	136–165	136–153	136–165	136–150
HVR 2	190–192	178–184	190–192	178–184	190–192	173–185
HVR 3	212–218	204–209	—b	—b	212–220	203–210
HVR 4	252–258	244–251	252–258	244–251	248–258	238–251
HVR 5	271–279	264–271	270–279	263–271	268–281	261–277
HVR 6	305–310	279–302	—b	—b	305–310	301–306
HVR 7	418–428	410–420	418–428	410–420	418–428	414–424
HVR 8	435–436	—c	435–436	—c	431–438	427–434
HVR 9	440–451	430–440	440–451	430–440	443–551	439–446

^aaa, amino acids.

^bThis HVR is not present in Ad43, so no additional amino acids are inserted.

^cThis HVR is not modified.