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Inhibition of let-7b attenuates IFN-α- and IL-28B-mediated anti-HCV activity. Huh7.5.1 cells infected with Jc1-Luc HCVcc were transfected with either a let-7b inhibitor (A) or an miR-122 mimic (B) 2 days prior to treatment with IFN-α (5 ng/ml) or IL-28B (50 ng/ml). The luciferase activity was measured 1 day after IFN treatment (means ± the standard deviations of three independent experiments; P values are from Student t tests; NS, no significance).
