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Reduced antigen-specific IgG in CD4 T cell-depleted animals. Total anti-gp140 plasma IgG from control and CD4 T cell-depleted macaques at day 42 postinfection was measured by ELISA. The mean anti-gp140 titers differed significantly between control (n = 2) and CD4-depleted (n = 4) animals by t test. The assay threshold of detection is indicated by a dotted horizontal line.
