Table 2.

Overview of experimental groups of mice and seveverity of vascular disease.

			Lesions*
Genetic	MCMV		Intima	Media	Adventitia
IFN-γR-/-	+	Genetic		++++	++++
IFN-γR-/-	+	-	++	++	++
Wild type	+	+	+	+	+
Wild type	+	-	0	0	0
Controls¶	-	-/+	0	0	0

MCMV = MCMV infection 4 months, IRR = whole body irradiation ^* = 0 – 4 + semi quantitative visual estimate. + = mild adventitial mononuclear cell infiltrate, no changes in the media or intima. ++ = significant adventitial inflammation also extending to the media, mild intimal thickening, +++ = in addition to adventitial and medial inflammation formation of neointima. ++++ = severe obliteration due to neointima formation in abdominal aorta, severe inflammation of adventitia and media characterized by breaks in the elastica. ¶ = wild type or IFN-γR-/- 129S mice receiving salivary gland homogenate from uninfected animals, + IRR in half.