Fig 2.
IL-17Rα−/− mice display an unimpaired IFN-γ response during pulmonary infection with F. tularensis SchuS4. C57BL/6 or IL-17Rα−/− mice (n = 4 to 5/group) were infected intratracheally (i.t.) with 50 CFU of F. tularensis SchuS4. At 48 or 96 h postinfection, RNA was extracted from the lungs and qRT-PCR was performed to determine the log2 induction of IFN-γ and IL-17 mRNA in infected mice compared to that of mock-infected mice (normalized to β-actin). Error bars represent SD. *, P < 0.05 compared to IL-17 induction by the same strain of mouse at the same time point.