Fig 4.
IL-17Rα is dispensable for oral LVS vaccine-induced immunity against pulmonary challenge with virulent F. tularensis. C57BL/6 or IL-17Rα−/− mice (n = 10 to 14/group) were treated orally with PBS or 1 × 108 CFU of F. tularensis LVS on 28 and 14 days before i.t. infection with 10 CFU of F. tularensis SchuS4. Body weights (A) and survival (B) were recorded. Mice that succumbed to infection were assigned a body weight of 75%. Error bars depict SEM. *, P < 0.05 compared to mice of the same genotype that were vaccinated with LVS. ^, P < 0.05 compared to LVS-vaccinated C57BL/6 mice.