Figure 3. Glucose flux through the glycolytic (Embden-Meyerhof) pathway and pentose phosphate pathway (PPP).

G6PD shunts glucose-6-phosphate away from glycolysis and into the oxidative arm of the PPP. Transketolase (TKT) and transketolase-like 2 (TKTL2) shunt xylulose-5-phosphate back into the glycolytic pathway. Only those glycolytic enzymes that are discussed specifically in the text are shown: glucose phosphate isomerase (GPI), PGAM1, PKM2, and LDHA and LDHB. Also shown are MCT4 and MCT1, which transport lactate out of and into cells, respectively.