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. 2013 Aug 27;123(9):4036–4049. doi: 10.1172/JCI69031

Figure 6. Stria vascularis function and barrier properties are normal in the TricR497X/R497X mice.

Figure 6

Hematoxylin and eosin labeling of paraffin-embedded inner ear sections showing (A) normal stria vascularis in 3-month-old Tric+/+ mice and (B) the thinning of this tissue seen in the TricR497X/R497X littermates. (C–J) Frozen sections made from (C, D, G, and H) Tric+/+ and (E, F, I, and J) TricR497X/R497X mice, respectively, after tracer injections into the oval and round windows of these animals at (C–F) 1 month and (G–J) 8 to 10 months of age. The biotin-based tracer molecule (in red) does not permeate through the basal cell layer of the stria vascularis in either the (D and H) Tric+/+ or (F and J) TricR497X/R497X mice. The nuclei of the intermediate and marginal cells are labeled with DAPI (blue). (K) EP in TricR497X/+ (dark gray bar) and TricR497X/R497X (light gray bar) mice (mean ± SEM; n = 5 for TricR497X/+, n = 6 for TricR497X/R497X; age of the animals: P25–P36). Scale bar: 50 μm (A and B); 20 μm (C–J).